Depression Major Depression		A major risk factor for suicidality is Major Depressive Disorder (MDD). There are clear criteria for making this diagnosis: ONE of the following for at least 2 weeks: Depressed or irritable mood for most of the day nearly every day Diminished interest or pleasure in activities that you used to be interested in or enjoy doing AND at least 4 of the following symptoms: Decreased/increased appetite, weight loss or gain, failure to achieve expected weight gain Insomnia or hypersomnia Psychomotor agitation/retardation or restlessness Low energy or fatigue Feelings of worthlessness or excessive guilt Poor concentration/memory Recurrent thoughts of death or suicide Return to top of page