Introduction
Clinical
Diagnosis
Bacteriology
Management
Initial
After Cx results
Negative Cx
Maternal antibiotics
Adjunctive therapy
Antibiotic Dosages
References
Other Lectures
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In addition to appropriate antibiotics, the management of sepsis may involve treatment of coagulopathy (either isolated thrombocytopenia or frank DIC), renal failure, shock, or adrenal failure. Drainage of local abscesses or abdominal surgery for NEC/perforations may also be necessary.
There are a number of newer therapies also being investigated. Granulocyte transfusion and administration of granulocyte-colony-stimulating factor (GCS-F) for septic neutropenic infants are still experimental therapies, owing to the fear of side effects, such as graft-vs-host reaction. More promising, although also still experimental, is the use of intravenous immunoglobulin (IVIG), based on the idea that septic newborns lack circulating antibodies against the bacterial organism.
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