Introduction
Clinical
Diagnosis
Bacteriology
Management
Initial
After Cx results
Negative Cx
Maternal antibiotics
Adjunctive therapy
Antibiotic Dosages
References
Other Lectures
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The choice of antibiotics to use is reevaluated after culture results and susceptibilities are available. In general, the safest, cheapest and most effective antibiotic should be used. The third-generation cephalosporins, in particular cefotaxime, have several advantages over the aminoglycosides. They do not exhibit the oto/nephrotoxicity of gentamycin, drug levels do not need to be monitored and they can be used in the face of decreased renal function. However, against this must be weighed the potential for development of antibiotic resistance with widespread use of these agents in the nursery.
The duration of therapy for sepsis is typically 10 days, with a repeat negative blood culture and at least 21 days with GBS or gram-negative meningitis. Pneumonia with a negative blood culture should be treated for 5-7 days with the initial antibiotics.
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